Spider-Man is defying orders in Infernal Hulk vs. Spider-Man #1, and he is doing it for one reason: the Richards kids are taken, New York is under siege, and the Avengers need a weapon to stop Infernal Hulk's rampage. Marvel Comics is sending the issue to local comic book retailers on Wednesday, November 4th, and the rescue mission is not framed as a side plot. It is the move that pushes the larger fight forward.
The mission matters because the Fantastic Four and the Baxter Building have already fallen to Infernal Hulk, leaving Spider-Man with no clean path and no safe choice. He goes after the Richards kids anyway, even if that means breaking with orders and turning the job into what is described as a suicide mission. The point is not just to save them. It is to get the Avengers the weapon they need to stop Infernal Hulk and keep the Age of Monsters from taking hold.
That is what gives the issue its weight. Spider-Man is not acting as part of a neat team plan; he is cutting across it. The Avengers need coordination and the right weapon, but the story puts him in motion before that plan can fully lock in. He moves because waiting would leave the Richards kids in Infernal Hulk's path, and because every step he takes now is meant to bring the weapon closer to the people who can use it.
The broader frame is already grim. Infernal Hulk has overrun the Fantastic Four, the Baxter Building has fallen, and New York remains under siege. This issue is part of the March to Hulk War, and it is described as the penultimate issue, which means the story is narrowing, not widening. The closer it gets to the finish, the more every rescue, every order ignored, and every delay in finding that weapon matters.
What happens next is already implied by the setup: Spider-Man is heading into danger to buy the Avengers a chance they do not yet have. Whether he gets the Richards kids out and whether the weapon arrives in time are the unresolved points, but the direction is clear. The fight is tightening around Infernal Hulk, and Spider-Man is choosing to run straight into the worst of it.

