More than half of the MMQB panel is calling for the Jacksonville Jaguars to upset the Denver Broncos in Week 2, even though Denver is favored and still carrying the sting of an opening loss to the Chiefs. The pick sheet turns that matchup into the clearest early read on how shaky the Broncos look after one week.
That is why the search for this address lands now. Week 2 opens with a Thursday night game between the Bills and the Lions, the Bills host the Lions in their regular-season debut at the new Highmark Stadium, and the rest of the slate is already being judged through the lens of opening-week results. The Patriots are trying to rebound from a season-opening loss against the Steelers, and the Chargers are trying to bounce back after falling to the Raiders. Against that backdrop, the Jaguars-Broncos game has become the week’s most pointed upset call.
The panel was not split evenly. Albert Breer, Eva Geitheim, Mitch Goldich, Mike Kadlick and Gilberto Manzano picked the Jaguars, while Conor Orr, John Pluym and Matt Verderame took the Broncos. Breer is a senior writer, Geitheim a news writer, Goldich a senior editor, Kadlick a senior news writer, Manzano a staff writer, Orr a senior writer, Pluym a managing editor and Verderame a staff writer. The result is a clear lean toward Jacksonville, with five of the eight pickers seeing the Broncos go down.
That tilt matters because Denver is not entering the game from a position of strength. The Broncos are favored, but they are doing it on short rest after an opening loss to the Chiefs, which is exactly the kind of setup that makes an early-season favorite vulnerable. Week 1 already produced four upsets, and this pick sheet suggests the panel thinks that volatility is not over yet.
There is one other warning sign tucked into the rest of the picks: only one picker sees the Rams falling to 0-2 against the Giants. That is a small number, but it reinforces the same larger message. The panel is willing to trust the safer-looking favorites in some places and still turn sharply against Denver in the one matchup that feels most exposed.
The Broncos and Jaguars will settle it in Week 2, and the question now is not whether Denver is favored. It is whether that favorite label survives another short-rest week after the Chiefs loss, or whether the MMQB panel has already spotted the upset before kickoff.
