Drew Lock will start at quarterback for the Seattle Seahawks in Week 2, giving the team a different look on the road Sunday against the Arizona Cardinals after Sam Darnold left the opener with a glute injury. The Seahawks game today carries extra weight because Seattle and Arizona both enter 1-0, but the quarterback change forces Seattle to lean on a different rhythm than the one it had in Week 1.
Lock finished Seattle's opener 16-of-22 for 187 yards and a touchdown after taking over, and that is the number that matters now. Seattle beat New England 13-10 while intercepting Drake Maye three times, then turned the week into a quarterback decision that was set well before kickoff in Glendale. The Seahawks visit the Cardinals on Sunday, Sept. 20, 2026, at 4:25 p.m. ET from State Farm Stadium in Glendale, Arizona.
That is why the betting line has held up even with both teams off to winning starts. Seattle is a 4-point favorite with a total of 41.5, which suggests oddsmakers still trust the Seahawks' overall profile more than Arizona's opener alone. Seattle's moneyline is -205 and Arizona's is +171, a setup that prices in the difference between a home underdog coming off a clean Week 1 and a road favorite that has already had to change quarterbacks.
Arizona earned its 26-14 win over the Chargers by doing a lot right at once. Jacoby Brissett threw for 277 yards and a touchdown, Trey McBride caught nine passes for 95 yards and a score, and the Cardinals finished with 393 total yards and no turnovers. Love also gave them a spark, running 11 times for 41 yards and a touchdown while adding two catches for nine yards, and the defense held up with 14 points allowed, three sacks and two takeaways.
That is the part that makes this matchup less tidy than the line suggests. Seattle is being asked to win with a backup starter against a team that did not waste possessions in Week 1 and that is tied for fifth in interceptions after forcing turnovers on defense. If Lock keeps the offense steady, Seattle can justify being favored; if he cannot, the game starts to look like the kind of divisional test that strips away the margin created by a single-week injury change.
So the next real answer comes at kickoff, when Seattle has to show whether its attack can travel with Lock in charge or whether Arizona's clean opener was the more reliable sign. The search for Seahawks game today ends with a simple question on the field: how much of Seattle's offense survives the change at quarterback in a game that already matters in the division?
