Amy Schumer said a botched colonoscopy left her “not feeling very sexual,” adding a blunt new chapter to the 44-year-old comic’s long list of health disclosures. She made the comment during a Not Skinny But Not Fat podcast event with Dear Media, where she said, “I actually had, kind of, a botched colonoscopy, so I’m not feeling very sexual.”
The remark landed after months in which Schumer had already been unusually open about what was happening to her body. In 2024, she wrote in the News Not Noise newsletter that she had been diagnosed with exogenous Cushing syndrome. Then, on the Call Her Daddy podcast in 2025, she said steroid injections had given her Cushing syndrome and told listeners she learned she had “moon face.” She also said she was starring in Netflix’s Kinda Pregnant when she became self-conscious about her appearance, with cameras in her face while she was feeling down on herself.
Schumer’s latest comments also sit inside a wider stretch of treatment and experimentation she has described publicly this year. In a March 2025 social media video, she said she tried Wegovy three years earlier and could not handle it because she was vomiting. She later said she went on a telehealth visit with Midi Health, was put on estrogen and progesterone after realizing she was in perimenopause, and that those symptoms had since disappeared. She has said her hair is fuller, her skin is better, she has more energy, and she wants to “get down more,” while adding that Mounjaro has been “great.”
That history matters because Schumer, unlike many public figures, has kept returning to the same subject with unusual candor: weight, hormones, medication side effects and the limits of what the body can tolerate. She has framed the experience as both medical and personal, saying of the steroid injections, “I was getting these steroid injections, and so it gave me this thing called Cushing syndrome; which I wouldn’t have known if the internet hadn’t come for me so hard.” She also said of her broader treatment approach, “I feel reborn,” and, “I feel happier than I’ve ever been before.”
The tension in her story is that the recovery she describes has not been neat or linear. She said the first round of Wegovy was unbearable, she described a period of self-consciousness while filming, and she has now added a colonoscopy mishap to the list. Schumer is currently separated from Chris Fischer, with whom she shares a son, Gene, but she gave no indication that the personal strain in her life has stopped her from talking publicly about what her body has been through. If anything, her latest remarks suggest she is still trying to explain, in real time, how one medical setback after another has shaped the version of herself she is now living in.
