’s Bills betting preview for Monday Night Football has put Matthew Stafford’s legs, Kyren Williams’ workload and Davante Adams’ route tree at the center of the matchup. The recommended player props line up with how the Los Angeles Rams have been moving the ball lately, even if the points have not followed at the same pace.
Stafford’s rushing line is the most unusual of the three. Over 2.5 rushing yards is priced at +100, and the setup is there because the quarterback had just one rushing yard across the whole 2025 regular season before this piece, then turned around and logged at least 10 rushing yards in each of his last two contests. That kind of swing matters in a game built around uncertainty, especially with Buffalo having allowed the fifth-most rushing yards to opposing quarterbacks. C.J. Stroud, Justin Herbert and Drake Maye all cleared double-digit rushing yards against the Bills, and Jared Goff added seven on the ground as well.
The Stafford number also fits the way this game could unfold if Buffalo forces Los Angeles into longer drives. The Bills need James Cook III to make the Rams respect the run, because the Rams are allowing 4.8 yards per pass attempt and will be hard to attack only through the air. Buffalo also needs Keon Coleman to give Josh Allen somewhere to go outside if DJ Moore sits. Allen has already shown how much volume he can carry in that spot, averaging 41.5 dropbacks when Buffalo was an underdog last season.
Williams is the other steady piece. His rushing yards over 68.5 is listed at -112, and he has rushed for 80-plus yards in three straight games. He has also added 16 catches over the past two weeks, which is part of why the Rams have kept leaning on him even as their offense has hit a scoring ceiling. Los Angeles is sixth in yards per play and plays at the fifth-fastest neutral pace, yet it averages only 21.3 points per game. That gap says the offense is efficient without always turning that efficiency into touchdowns, which is why a heavy Williams role still feels like the safest part of the bet.
Adams brings the final piece. His 70+ receiving yards line sits at +123, and he has cleared it in two of four games this season. Both of those games came with Puka Nacua inactive, which is the kind of split that makes the bet less certain, even though the Bills have allowed the fourth-most receiving yards to wide receivers. Nacua can hurt Buffalo across the middle, Adams can attack outside, and the Rams’ recent run through San Francisco, Denver and Philadelphia has already shown how often they can move the ball without cleanly finishing drives. That is also why Buffalo’s defense matters here: it has been bottom 10 in points per play allowed, and Los Angeles has committed multiple turnovers in four straight games, a clash of traits that leaves room for a game that is productive, messy and still decided by a handful of plays.
That is the read bettors have to make before kickoff: whether the Rams’ yardage edge finally turns into points, or whether Buffalo’s pressure points keep the game in the range where Stafford’s scrambling, Williams’ touches and Adams’ volume all cash before the night is over.
