Drew Lock will start for the Seattle Seahawks in Week 2 when they visit the Arizona Cardinals on Sunday, Sept. 20, 2026, after Sam Darnold left Seattle's opener early with a glute injury. The game is set for 4:25 p.m. ET at State Farm Stadium in Glendale, Arizona.
That is the immediate draw for Seahawks Vs Cardinals: a division game between two 1-0 teams with Seattle adjusting at quarterback. Lock completed 16 of 22 passes for 187 yards and a touchdown in the opener, helping Seattle beat New England 13-10 despite the early injury, while Arizona opened with a 26-14 win over the Chargers.
The records explain why this meeting has early-season weight. Seattle intercepted Drake Maye three times in its win and posted a 109.7 passer rating without turning the ball over, while Arizona answered in its own opener with 393 total yards, no turnovers, and a defense that allowed 14 points, recorded three sacks and forced two takeaways.
The Cardinals also brought their own offensive evidence to the matchup. Jacoby Brissett threw for 277 yards and a touchdown against the Chargers, and Trey McBride caught nine passes for 95 yards and a score, giving Arizona a passing game that arrived sharp and efficient in Week 1.
The unresolved piece is Seattle's quarterback picture beyond Sunday. Drew Lock is the starter for Week 2, but Sam Darnold's availability is not confirmed in the facts, and that leaves the Seahawks carrying a change under center into a road game where the line already makes them 4-point favorites with a total of 41.5. The market has given Seattle the edge, but the game will still be shaped by whether the Seahawks can keep the same control they showed in Week 1 without knowing how quickly their quarterback situation settles.
