No. 9 Ole Miss will host No. 13 Missouri on Saturday, October 17, 2026, at 3:30 p.m. ET in Oxford, Mississippi, putting two winning teams in the same stadium at a time when every SEC result carries extra weight. The Rebels are 4-1 and Missouri is 5-1, but the records alone do not tell the whole story: Ole Miss is a 6-point favorite, with the total set at 59.5 and the moneyline at -225 for the Rebels and +179 for the Tigers.
That line helps explain why Missouri vs Ole Miss is drawing attention now. Ole Miss comes in off a 52-17 win over Vanderbilt in Week 6, while Missouri beat Texas A&M 27-6 in its own Week 6 game, so both teams arrive with confidence after convincing results. Trinidad Chambliss led Ole Miss with 213 passing yards, three touchdowns and a rushing score against Vanderbilt, and Kewan Lacy returned from a shoulder injury to add 39 yards and a touchdown on seven carries before sitting out the second half.
Missouri has its own offensive rhythm, but the Tigers are also carrying a number that sharpens the matchup: their passing game has 14 touchdowns against one interception. That lone interception came when Austin Simmons was picked off against Texas A&M on Oct. 10, even though the quarterback had thrown for 340 yards at 11.3 per attempt against Florida on Oct. 3 and has 1,434 yards on 107 of 165 passing this season. Ole Miss has leaned on Chambliss, who has 1,435 yards on 122 of 174 passing with 11 touchdowns and four interceptions, while the Rebels have also piled up nine sacks in five games and 31 tackles for loss. Missouri has 18 sacks in six games and has allowed 16.7 points per game, which is why this game reads less like a ranking exercise and more like a test of which front can force the other side out of its comfort zone.
The matchup also comes with a direct contrast in how the teams have won lately. Missouri has taken its last two games by 28 and 21 points, while Ole Miss is trying to build on a week in which Chambliss found Deuce Alexander and Lacy helped keep the offense balanced. Jamal Roberts, who ran for a career-high 222 yards and two touchdowns on 34 carries against Texas A&M, gives Missouri a backfield threat that can slow the pace and keep pressure off the passing game. Saturday in Vaught-Hemingway Stadium will decide whether Ole Miss can defend its ranking at home or whether Missouri can turn a strong record and a stingy defense into a road upset.
